منابع مشابه
Lysosomes
I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...
متن کاملLysosomes
Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....
متن کاملLysosomes for lunch
I f an intracellular parasite is too successful at hiding itself, it can end up starving. Toxoplasma gondii gets around this potential problem by munching nutrient-fi lled host lysosomes, say Isabelle Coppens and colleagues. T. gondii has an extraordinary mechanism for creating a parasitophorous vacuole (PV) around itself—it motors into a host mammalian cell and uses a ring-shaped moving juncti...
متن کاملRegulating secretory lysosomes.
Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of...
متن کاملLysosomes and Membrane Recycling
A mechanism for intralysosomal membrane recycling is proposed. After invagination of the lysosomal membrane during autophagy, intralysosomal vesicles are formed. It is suggested that membrane can bleb out from these internal vesicles, probably in the form of very small vesicles, and return to the external lysosomal membrane by membrane fusion. This mechanism would conserve lysosomal membrane du...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2009
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2009.03.001